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M9480571.TXT
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1994-08-20
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Document 0571
DOCN M9480571
TI Nitric oxide synthesis in patients with advanced HIV infection.
DT 9410
AU Evans TG; Rasmussen K; Wiebke G; Hibbs JB Jr; Infectious Disease Section
(111L), Salem VAMC, VA 24153.
SO Clin Exp Immunol. 1994 Jul;97(1):83-6. Unique Identifier : AIDSLINE
MED/94306757
AB The discovery that humans produce nitric oxide and that this molecule
plays an important role in cell communication, host resistance to
infection, and perhaps in host defence to neoplastic disease, has
created much interest in further research on its function in the body. A
cytokine-inducible high output L-arginine/nitric oxide pathway was
recently detected in patients with advanced malignancy treated with
IL-2. The production of nitric oxide was thus examined in patients with
advanced HIV infection and in intensive care unit control patients.
Extrinsic nitrate and nitrite consumption were carefully controlled in
the diet or through the use of total parenteral nutrition. Seven of
eight HIV+ patients were placed into positive nitrogen balance. Nitric
oxide synthesis was found to be within the normal human range. In
contrast, nitric oxide synthesis in extremely ill intensive care unit
patients was low normal to depressed.
DE Adult Critical Illness Diet Female Human HIV Infections/*METABOLISM
Male Nitrates/ADMINISTRATION & DOSAGE/URINE Nitric Oxide/*BIOSYNTHESIS
Nitrogen/METABOLISM Reference Values Support, U.S. Gov't, Non-P.H.S.
Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).